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The Link Between Estrogen, Cancer, and the One Factor You Probably Haven’t Considered

Updated: Nov 19



Many of us know that lifestyle choices, diet, and environmental factors play a role in hormonal health, especially when it comes to estrogen-related issues. From painful periods to bloating, mood swings, and even increased cancer risk, estrogen imbalances can have a profound effect on our lives. But there’s a piece of the puzzle that’s often overlooked: your gut microbiome.


Recent research suggests that the gut – specifically a unique set of bacteria called the estrobolome – has a significant impact on how estrogen is processed in the body. And while you may not hear much about the estrobolome, understanding it could be key to managing symptoms like estrogen dominance and supporting long-term health for both men and women.


How Estrogen Dominance Affects Your Health

For women, estrogen dominance can lead to symptoms like:

  • Bloating and water retention

  • Tender breasts

  • Heavy or irregular periods

  • Mood swings and irritability

  • Fatigue

  • Weight gain around the hips and thighs


For men, excess estrogen can also cause issues, such as gynecomastia (the development of breast tissue), fatigue, and weight gain, often due to a process called aromatization, where testosterone converts into estrogen.


While these symptoms are frustrating, estrogen dominance is also linked to more severe concerns, such as an increased risk for certain cancers. High levels of estrogen, when unbalanced by other hormones like progesterone (in women) or testosterone (in men), have been associated with conditions like breast, ovarian, and prostate cancer. And while there are many factors that contribute to this imbalance, gut health is one that’s frequently overlooked.


What the Estrobolome Does with Estrogen

The estrobolome is a specialized part of the gut microbiome, responsible for breaking down estrogen and helping the body to either eliminate it or keep it in circulation. The bacteria within the estrobolome produce enzymes that determine whether estrogen is inactivated for removal or reabsorbed into the bloodstream.


When the estrobolome is healthy, it ensures that just the right amount of estrogen is processed and eliminated. But when it’s out of balance, often due to stress, poor diet, or antibiotic use, more estrogen can be reabsorbed. This not only contributes to estrogen dominance but also places both men and women at risk for hormonal imbalances and related health issues.


Men, Testosterone, and the Role of Gut Bacteria

While we often think of estrogen as a female hormone, it plays an essential role in men’s health, too – and the estrobolome plays a part in regulating it. Men naturally produce estrogen, although in smaller amounts. However, the enzyme aromatase can convert testosterone into estrogen, especially when testosterone levels are higher or when there’s an imbalance in gut health.


An imbalanced gut microbiome, particularly one with a compromised estrobolome, can result in increased aromatization. This can lead to symptoms of excess estrogen in men, such as fatigue, weight gain, and reduced libido. For both men and women, an imbalanced estrobolome means more estrogen in the system than necessary, leading to not only day-to-day symptoms but also long-term health risks, including cancer.


Supporting the Estrobolome for Better Hormonal Health

So how do you keep your estrobolome functioning optimally? Here are some actionable steps:

  1. Eat a Fiber-Rich Diet: Fiber is essential for gut health, as it supports regular elimination and helps carry excess estrogen out of the body. Leafy greens, cruciferous vegetables (broccoli, cauliflower, Brussels sprouts), and whole grains are great sources.

  2. Incorporate Probiotics and Prebiotics: Probiotics (like those in fermented foods such as sauerkraut, yogurt, and kimchi) add beneficial bacteria to your gut. Prebiotic foods like garlic, onions, and bananas feed those good bacteria, helping maintain a balanced estrobolome.

  3. Avoid Processed Foods and Reduce Alcohol Intake: Processed foods and alcohol can disrupt gut bacteria, making it harder for the estrobolome to function effectively. Opting for whole foods and keeping alcohol consumption moderate can help keep things on track.

  4. Consider Gut Health Testing:  To get a better picture of how your estrobolome is functioning, consider gut health testing. This can identify imbalances and help you find personalized ways to support your microbiome. Click here to book a discovery session to learn how you can get started on this journey and discover the best options for your unique needs.

  5. Manage Stress and Prioritize SleepChronic stress and lack of sleep can both disrupt the gut microbiome. Incorporate relaxation techniques, regular physical activity, and good sleep hygiene into your routine to support both your nervous system and your estrobolome.


The Bottom Line

Hormone health isn’t just about what you eat or whether you exercise. It’s about nurturing the microbiome, specifically the estrobolome, so your body can process and balance estrogen properly. When we take care of our gut health, we’re not only helping to reduce symptoms like bloating, heavy periods, and mood swings but also supporting long-term health in ways that matter – including reducing the risk of hormone-related cancers.


 

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